3-(p-Hydroxyphenyl)-2-oxopropanoic acid
4-Hydroxyphenylpyruvic acid
CAS: 156-39-8
Molecular Formula: C9H8O4
3-(p-Hydroxyphenyl)-2-oxopropanoic acid - Names and Identifiers
3-(p-Hydroxyphenyl)-2-oxopropanoic acid - Physico-chemical Properties
| Molecular Formula | C9H8O4 |
| Molar Mass | 180.16 |
| Density | 1.2933 (rough estimate) |
| Melting Point | 219-220 °C (dec.) (lit.) |
| Boling Point | 272.96°C (rough estimate) |
| Flash Point | 230.516°C |
| Water Solubility | slightly soluble |
| Solubility | Solubility in water: slightly soluble Solubility in other solvents: soluble in ether, al |
| Vapor Presure | 0mmHg at 25°C |
| Appearance | off-white to yellowish brown crystals |
| Color | off-white to tan |
| BRN | 2691632 |
| pKa | 2.50±0.54(Predicted) |
| Storage Condition | Inert atmosphere,Room Temperature |
| Stability | Hygroscopic |
| Refractive Index | 1.4500 (estimate) |
| MDL | MFCD00002591 |
3-(p-Hydroxyphenyl)-2-oxopropanoic acid - Risk and Safety
| Hazard Symbols | Xi - Irritant |
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection |
| WGK Germany | 3 |
| RTECS | UZ1000000 |
| HS Code | 29189900 |
3-(p-Hydroxyphenyl)-2-oxopropanoic acid - Reference Information
| NIST chemical information | Information provided by: webbook.nist.gov (external link) |
| Biological activity | 4-Hydroxyphenylpyruvic acid (4-HPPA) is a rich polyphenol colon metabolite and an effective scavenger that can inhibit free radicals and cyclooxygenase-2 (COX-2) levels and help reduce the risk of colon cancer development. |
| Target | Value |
| production method | 1. preparation method: p-hydroxyphenylaldehyde hydrazone (4): add p-hydroxybenzaldehyde (2)6.11g(0.05mol), hydrazone (3)5.5g(0.055mol), dried piperidine 10mL, and install a reflux condenser (containing calcium chloride drying tube) into a round bottom flask. The oil bath is slowly heated to 130 ℃ and reacted for 30min. Bubbles and boils in. Cool and add 200mL of water at 60 ℃. Stir until a clear liquid is produced. Filtration, the filtrate is cooled and acidified with about 20mL concentrated hydrochloric acid. Leave at room temperature for several hours. The yellow precipitate generated by filtration is washed in cold water. Dry in a vacuum dryer containing potassium hydroxide to obtain crude product (4)8.5~8.8 with a yield of 83% ~ 86% and mp310 ~ 315 ℃. Directly for the next reaction. p-hydroxyphenylacetonic acid (1): 8.5g(0.042mol) of compound (4) is added to a reaction bottle equipped with a stirrer, a reflux condenser, a dropping funnel and a ventilation catheter, high purity nitrogen is introduced, and 240mL of 20% sodium hydroxide solution is added dropwise. Heat and boil at 170~180 ℃ in oil bath for 3 hours. Compound (4) dissolves quickly, forming a clear orange solution, and the color becomes darker in the reaction. Cooling in the water bath, continue to inject nitrogen, add about 100mL of concentrated hydrochloric acid dropwise to neutralize the alkali, control the drip acceleration, and do not form a large amount of foam and obvious heat release. Slowly add 5g of sodium bicarbonate to dissolve it. The reaction liquid is transferred into a continuous extractor and extracted with ether until the ether layer is colorless. It takes about 2 hours. The ether layer is separated, the water layer is carefully acidified with 60mL of concentrated hydrochloric acid, and then transferred to the extractor for extraction with ether until there is no more p-hydroxyphenylacetone acid in the ether layer. The ether layer is concentrated to dry to give a yellowish solid crude (1). Drying in a really fast dryer containing potassium hydroxide to obtain 6.9-7.2g of crude product (1) with a yield of 92%-96% and mp210 -215 ℃ (decomposition). Add 12mL of water (83~86mL) to each gram of crude product (1), reflux in an oil bath at 150 ℃, and then generate light yellow dissolution after 10~20min, and filter. Add 8.3~8.6mL concentrated hydrochloric acid (1.2mL per gram of acid), slowly cool to room temperature, and stir from time to time. After being placed in the refrigerator for 10~20min, a light yellow solution is generated and filtered. Add 8.3~8.6mL concentrated hydrochloric acid (1.2mL per gram of acid), slowly cool to room temperature, and stir from time to time. Place in the refrigerator for 10h, filter, wash with cold water, and dry to obtain compound (1)4.4~4.7g, yield 59% ~ 63%,mp216~218 ℃ (decomposition). [1] |
Last Update：2024-04-09 20:49:11
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